To make the burger sauce, in a small bowl stir together all of the ingredients until well-combined. Give it a taste and adjust seasoning accordingly, adding more salt or pepper if needed. Cover with plastic wrap and store in the fridge until ready to serve.
Set a large skillet over medium-high heat. Once hot, add the bacon and cook, stirring often, until crispy about 5 to 8 minutes. Using a slotted spoon, transfer the bacon onto a plate lined with paper towels. Drain all but 1 tablespoon of the fat, and crumble in the ground beef. Using a wooden spoon, break up the beef and cook until crispy and no longer pink, about 10 to 12 minutes. Season with salt, pepper, onion, garlic, and Worcestershire sauce. Remove from heat and cool slightly.
To assemble, toss the lettuce in a large bowl with a few spoonfuls of the burger sauce. Transfer to 4 serving bowls and top each with the ground beef, bacon, pickles, red onion, tomatoes, cheese, sesame seeds and more of the burger sauce. Serve immediately and enjoy!